How Pain Works Nerves, Inflammation, and Why Pain Persists

Understanding the science of pain — and how modern treatments can finally help you feel better.


Pain is one of the most common reasons people seek medical care, yet it’s also one of the least understood. Many patients are told “your MRI looks fine,” or “your pain should be gone by now,” but they still hurt.

At Cedar Rapids Pain Associates, we believe patients get better when they understand why their pain happens — and more importantly, why it sometimes lingers long after an injury has healed.

This guide breaks down pain in simple terms:

  • how your nervous system creates pain,
  • how inflammation drives pain signals,
  • why pain sometimes becomes chronic,
  • and which treatments can help “reset” the pain cycle.

1. Pain Starts in the Nervous System

Pain is not created in the body part that hurts — it is created in the brain.

Here’s the pathway:

📌 Step 1: Something triggers a pain signal

This could be:

  • an injury
  • inflammation
  • muscle spasm
  • compressed nerve
  • irritated joint

Special sensors (nociceptors) send a message up the spinal cord.

📌 Step 2: The brain interprets the signal

Your brain decides:

  • How bad is this?
  • Do I need to protect this area?
  • Am I in danger?

This is why two people with the same injury may feel very different levels of pain.

Pain = the brain’s protective alarm system.

The goal of treatment is not simply to “cover up pain” —
it’s to calm the alarm system down.


2. Inflammation: The Fuel Behind Most Pain

Inflammation is your body’s natural healing response. But when it lasts too long or becomes excessive, it turns into the gasoline that keeps pain burning.

Why inflammation causes pain:

  • Swollen tissues press on nerves
  • Chemical irritants sensitize nerves
  • Muscles tighten to guard the painful area
  • Blood flow changes affect healing

Common conditions driven by inflammation include:

  • sciatica
  • arthritis
  • tendonitis
  • herniated or bulging discs
  • plantar fasciitis
  • chronic neck and back pain

When inflammation is reduced, pain often decreases dramatically.


3. Why Pain Sometimes Becomes Chronic

Sometimes the original injury heals…
but the pain system gets stuck in “overprotective mode.”

This is called central sensitization.

Signs this may be happening:

  • Pain lasts longer than 3–6 months
  • Pain spreads beyond the original area
  • Normal activities trigger pain
  • Weather, stress, or poor sleep worsen symptoms

In this state, the nervous system becomes extra sensitive, like a car alarm that goes off too easily.

This is why long-term pain needs a different approach than short-term injuries.


4. The Pain Cycle — And How We Break It

Chronic pain creates a loop:

  1. Injury →
  2. inflammation →
  3. nerve irritation →
  4. muscle tension →
  5. reduced mobility →
  6. more inflammation and nerve sensitivity →
  7. more pain

The key to real relief is interrupting this cycle at multiple points.

That’s where a multidisciplinary clinic like ours has a major advantage.


5. Modern Treatments That “Reset” the Pain System

At Cedar Rapids Pain Associates, we use treatments that target both inflammation and nerve sensitivity — giving patients long-lasting relief.

Epidural Steroid Injections & Nerve Root Blocks

Reduce inflammation around irritated spinal nerves (great for sciatica and disc-related pain).

🔥 Radiofrequency Ablation (RFA)

Works by stopping overactive pain nerves from sending chronic pain signals.

💉 PRP (Platelet-Rich Plasma) Injections

Helps repair damaged tissues and reduce inflammation naturally.

🔷 MLS Robotic Laser Therapy

Reduces inflammation, improves blood flow, and calms irritated nerves — great for arthritis, tendonitis, and nerve pain.

💥 Shockwave Therapy

Breaks up scar tissue, increases circulation, and stimulates healing — extremely effective for chronic tendon pain.

🌀 Spinal Decompression Therapy

Relieves pressure on discs and nerves, helping reduce pain without surgery.

💉 Trigger Point Injections

Relieve painful muscle knots that cause tightness, spasms, and referred pain in the neck, shoulders, back, and hips.

🦵 Joint Injections (Knee, Shoulder, Hip, SI Joint)

Reduce inflammation inside arthritic or irritated joints, improving mobility and decreasing pain without surgery.

💪 Physical Therapy & Chiropractic Care

Improves movement patterns, reduces muscle tension, strengthens support muscles, and helps retrain the nervous system.

📦 Supplements & At-Home Support

Biogenetix anti-inflammatory and nerve-support supplements help maintain progress between treatments.

6. Pain Is Real — And Treatable

If you’ve been told your pain is “in your head,” know this:

**Your pain is real.

Your nervous system is real.
And real treatments exist to fix the problem — not mask it.**

Patients come to us after months or years of frustration, and with the right plan, they finally get relief.


7. When to See a Pain Specialist

You don’t need to wait months.
You don’t need a referral.
And you don’t need to “just live with it.”

You should see a pain specialist if:

  • pain has lasted more than 4–6 weeks
  • you’ve tried rest, medication, or chiropractic with limited relief
  • pain is affecting sleep, work, or daily activities
  • pain is shooting down your leg or arm
  • you’re considering surgery and want alternatives

Ready to Break the Pain Cycle?

At Cedar Rapids Pain Associates, we help patients find relief quickly, using a proven multidisciplinary approach.

📞 Call (319) 294-0094
🌐 Schedule at CRPainFree.com
No referral needed
🗓️ Appointments often available this week

Let’s get you back to living pain-free.

Call Us Text Us
Skip to content